Ketamine: chronology of a clinical revolution
We delve into the development and use of ketamine since its creation in 1962.
Debora Gonzalez
18/12/2025
Contenido de la caja
We delve into the development and use of ketamine since its creation in 1962.
We review some of the published studies that investigate the use of ketamine for anxiety.
Can ayahuasca help us with the grieving process? We explore this in this post.
We review some of the key differences between these management methods
What is neuroplasticity and what effect does ketamine have on it?
Treatment-resistant depression affects up to one third of patients with major depressive disorder and is linked to severe impairment and suicide risk. Real-world clinical data show that ketamine offers rapid antidepressant effects, with meaningful symptom reduction in nearly half of treated patients and remission in around one third. Benefits often appear within hours or days and can be maintained over time with follow-up treatment. Evidence also indicates good tolerability, low risk of symptom worsening and effectiveness in both unipolar and bipolar depression.
In this article we explain the differences between S-Ketamine and R-Ketamine from different studies, evidences and results. We will see the different effects and applications they can have.
This article explains the key differences and similarities between ketamine and esketamine in the treatment of resistant depression. It reviews their shared glutamatergic mechanisms, distinct stereoisomeric forms, routes of administration and side effect profiles. Evidence from preclinical and clinical studies suggests racemic ketamine and R-ketamine may offer longer lasting antidepressant effects and fewer adverse reactions than S-ketamine. The text also addresses subjective experiences, dissociative effects, cost, regulatory issues and why many clinics prioritize racemic ketamine in personalized, evidence based care.
We talk about psilocybin and it’s therapeutic uses
At the end of September and beginning of October 2025 we will carry out two Ketamine-assisted Psychotherapy trainings together with Phil Wolfson.
An introduction to the speakers of our training
We explore the potential benefits of microdosing, as well as safety considerations and current scientific evidence.
Discover the differences between ketamine and psilocybin therapy: mechanisms, legality, efficacy, and clinical applications in mental health.
Discover group therapy at our clinic in Barcelona. A safe space to share, grow, and improve your emotional well-being with professional support.
Read on to find out more about Holotropic Breathwork
The Ketamine Research Foundation (KRF), led by Dr. Phil Wolfson,
We explore the use of psychedelic therapy in the treatment of grief
Psilocybin and Depression Depression affects approximately 280 million people worldwide,
How important is music in the sessions? We discuss it in this post
New interview on YouTube with the researcher and psychologist José Carlos Bouso
We talk about fear and trauma, discussing the possible use of MDMA for the treatment of PTSD
Interview on youtube about ketamine-assisted psychotherapy in Ukraine
Interviews with Phil Wolfson, CEO of the KRF
At Clínica Synaptica we consider psychoeducation to be an important tool that can be of great benefit in the therapeutic process. Psychoeducation is a way of accompanying and sharing knowledge about mental health issues that promotes self-knowledge.
Phil Wolfson, the creator of ketamine-assisted psychotherapy, answers some questions about the current landscape in the field
In this post we talk about chronic pain and the possibility of treatment with ketamine-assisted therapy
Can ketamine work where classic antidepressants have not worked?
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