Ketamine
Ketamine-assisted therapies have established themselves as an advanced option for individuals who require a more effective approach to intense emotional symptoms or those resistant to other treatments. In controlled doses, ketamine can rapidly reduce emotional distress and generate a state of greater clarity that facilitates therapeutic work.
This approach combines the neurobiological effects of the substance with structured psychological support, allowing the experience to be integrated and promoting stable changes in well-being. The entire process is carried out in specialised clinical settings, under professional supervision and following strict protocols to ensure safety, efficacy and continuous support during each phase of treatment
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📢 MINI CONFERENCE: PSYCHEDELICS AND MENTAL HEALTH 2026
On 20 March, Málaga will host a series of talks exploring the relationship between psychedelics and mental health. Specialists and professionals will discuss current research, their therapeutic potential and the challenges of…
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Building new paradigms in mental health: the practice of ketamine-assisted psychotherapy
As part of the project “Let’s Talk Openly About Mental Health”, Dr Estefanía Moreno took part in a public talk held in Gràcia (Barcelona) on new paradigms in mental health. On behalf…
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How Can Ketamine Therapy Help You?
Ketamine therapy has gained relevance in mental health as an option for treatment-resistant depression, anxiety, and PTSD. Discover how it works, what a session involves, and why it’s often combined with psychotherapy…
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Rewiring the Soul: 5 Surprising Ways Psychedelics Reshape Who We Are
For centuries we believed personality was fixed, carved in stone by adulthood. A new systematic review — analyzing 48 studies on psilocybin, LSD, and ayahuasca — suggests otherwise: our deepest traits, from…
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Foundations of Ketamine-Assisted Psychotherapy: A One-Day Introductory Course
This years Ketamine-Assisted Psychotherapy training expands theoretical and experiential learning for health professionals. In this blog we go over our Foundations one-day KAP course. Join us to learn more!
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KAP International Association Summit
A nine-day gathering held in Barcelona on 15–23 October 2026 on ketamine-assisted psychotherapy: the 1st KAP International Association Summit, an introductory workshop and a residential training.
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Phil Wolfson: an in-depth interview
In this engaging interview conducted by Dr. Joan Obiols, Phil Wolfson, founder of the Ketamine Research Foundation, speaks passionately about the pivotal events in his life and what led him to become…
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Ketamine: chronology of a clinical revolution
Ketamine’s clinical journey spans more than six decades, evolving from a battlefield anesthetic to a groundbreaking therapeutic tool in mental health. Its history reflects a convergence of neurobiological discovery, clinical intuition, and…
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Ketamine for anxiety: a simple guide to new findings
Anxiety disorders are increasingly prevalent and often respond poorly to standard treatments such as SSRIs or benzodiazepines. Growing evidence suggests ketamine-assisted psychotherapy may offer rapid relief, particularly in treatment-resistant anxiety. By modulating…
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Comparing intravenous vs. intramuscular ketamine therapy
Ketamine therapy can be delivered intravenously or intramuscularly, each offering distinct therapeutic experiences. IV administration provides gradual delivery, precise titration and close monitoring, often preferred in acute settings. IM administration offers rapid…
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Neuroplasticity and ketamine: a new horizon in mental health
Depression, anxiety and chronic stress are associated with the loss and retraction of dendritic spines, disrupting communication between key brain regions involved in emotion, memory and decision-making. This disconnection reduces cognitive flexibility…
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Ketamine for Treatment Resistant Depression: Real World Evidence
Treatment-resistant depression affects up to one third of patients with major depressive disorder and is linked to severe impairment and suicide risk. Real-world clinical data show that ketamine offers rapid antidepressant effects,…
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Are S-Ketamine (Esketamine) and R-Ketamine the same?
This article explains the key differences and similarities between ketamine and esketamine in the treatment of resistant depression. It reviews their shared glutamatergic mechanisms, distinct stereoisomeric forms, routes of administration and side…
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Ketamine administration methods
Ketamine-assisted psychotherapy can use several routes of administration, each with different pharmacokinetic profiles. This article explains bioavailability and half-life, and compares intramuscular, intranasal and oral ketamine. Intramuscular administration offers very high bioavailability,…
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Meet the speakers of the training on ketamine-assisted psychotherapy in Barcelona
This article introduces the speakers for the Ketamine-Assisted Psychotherapy training program taking place in Barcelona in 2025. The program brings together internationally renowned professionals in psychiatry, psychology, neuroscience, and psychedelic therapies. The…
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Ketamine vs. psilocybin therapy: a comparative overview
This article compares ketamine and psilocybin-assisted therapies, outlining differences in legality, mechanisms of action, therapeutic uses, safety profiles and patient experience. Ketamine is legally available and offers rapid symptom relief through glutamatergic…
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Guidelines for ketamine safety and clinical use: Ketamine Research Foundation recommendations
The Ketamine Research Foundation, led by Dr. Phil Wolfson, has published a comprehensive guide for the safe and ethical use of ketamine. The document addresses responsible personal use, clinical application within ketamine-assisted…
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Ketamine-assisted therapy in the treatment of grief for the loss of a loved one
Prolonged or complicated grief affects around 10% of bereaved people and is marked by persistent longing, intense emotional distress, and functional impairment. Current evidence shows only moderate benefits from psychotherapy and no…
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Ketamine for chronic neuropathic pain
Chronic neuropathic pain is often severe, persistent, and poorly responsive to conventional treatments such as anti-inflammatories or opioids. Ketamine has emerged as a promising option by modulating NMDA receptors involved in pain…
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New interview with Dr. Vladislav Matrenitsky, kyiv, Ukraine
During our recent Ketamine-Assisted Psychotherapy training, we had the privilege of welcoming Vladislav Matrenitsky, founder of Expio Clinic in Kyiv. A medical doctor and transpersonal psychotherapist, Dr. Matrenitsky integrates psychedelic medicine with…
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Phil Wolfson: ketamine, consciousness and emotional healing
Phil Wolfson, creator of Ketamine-Assisted Psychotherapy (KAP) and director of the Ketamine Research Foundation, shares an in-depth reflection on his life, clinical work, and the future of psychedelic medicine. In this interview,…
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Interview with Phil Wolfson
Phil Wolfson, creator of Ketamine-Assisted Psychotherapy (KAP) and director of the Ketamine Research Foundation, shares his vision on the future of psychedelic psychotherapy in this in-depth interview. Drawing from decades of clinical…
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Chronic pain: a debilitating affliction
Chronic pain is a complex condition lasting more than three months that affects millions of people and severely impacts quality of life. It includes multiple forms such as neuropathic, musculoskeletal, cancer-related and…
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Treatment-Resistant Depression: When Nothing Else Works
Treatment-resistant depression occurs when major depressive disorder does not respond to at least two adequate treatments, leading to prolonged suffering and functional impairment. Many patients fail to achieve full remission, despite multiple…
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Ketamine for suicide prevention
Suicidal ideation represents a major public health concern and requires rapid, effective intervention. Conventional treatments such as antidepressants and psychotherapy often act too slowly for high-risk patients. Recent clinical evidence shows that…
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Ketamine in therapy: how does it work?
From its synthesis in 1962 to its current use in mental health, discover how ketamine acts on NMDA receptors, glutamate, and BDNF to support neuroplasticity and relieve depressive symptoms.
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Addiction in our society
Addiction is a complex condition influenced by biological, psychological, and social factors, often associated with high relapse rates despite available treatments. Research shows that ketamine may offer a novel therapeutic approach by…
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Ketamine-assisted psychotherapy for post traumatic stress disorder
Posttraumatic stress disorder (PTSD) involves intrusive memories, hyperarousal, dissociation, avoidance, and high comorbidity with depression, anxiety, and substance use. Standard treatments combine psychotherapy and antidepressants, yet remission rates remain low. Ketamine-assisted psychotherapy…
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Ketamine and depression: the first days of treatment
Depression is a complex disorder affecting mood, cognition, and physical health, and is the leading cause of disability worldwide. Standard treatment combines antidepressant medication and psychotherapy, yet around one third of patients…